?? ???? ????????? ?? ???? ?? ???????? ???????? ?????? ??? ?????? ??? ??? ?? ???? ???? ????????? ?? ???? ????? ?????? ?????? ????? ????? ???? ????? ?? ????? ??? ????? ?????? ????? ????.?????? ????? ?????? ??? ???????? ??????? ?? ??? ???? ??? ?? ???????.In individuals with creatinine clearance premiums under fifty mL/min, commence OPANA ER from the o